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Gotu Kola

The Herb of Cellular Renewal and Mental Clarity

Centella asiatica, also known as Gotu Kola, is a traditional medicinal herb widely used across Southeast Asia and now recognized by modern science for its unique cellular protective, cognitive-enhancing, and anti-inflammatory effects. What makes this plant truly special is its ability to support nervous system balance, microcirculation, and tissue regeneration, while also functioning as a powerful adaptogen.

Active Constituents

  • Centella asiatica contains a range of potent phytochemicals:
  • Asiaticoside and madecassoside – triterpene saponins that promote wound healing, collagen synthesis, and inflammation reduction
  • Asiatic acid and madecassic acid – triterpenoids with neuroprotective and antioxidant properties
  • Flavonoids and polyphenols – protect cells from oxidative stress

Clinically Proven Benefits

1. Cognitive Function and Neuroprotection
Centella’s active compounds have been shown to enhance memory, learning capacity, and concentration, while protecting neurons from oxidative and inflammatory damage. Both clinical and preclinical studies suggest it may lower the risk of neurodegenerative diseases, such as Alzheimer’s, by supporting acetylcholine synthesis and improving cerebral blood flow.

2. Stress Relief and Adaptogenic Effects
Centella asiatica helps regulate the HPA (hypothalamic-pituitary-adrenal) axis and has been shown to reduce symptoms of anxiety and chronic stress. A 2021 study confirmed that among natural adaptogens, Centella is particularly effective in restoring mental balance under emotional overload.

3. Anti-Inflammatory and Antioxidant Cellular Protection
Its triterpenes and flavonoids suppress the production of pro-inflammatory cytokines like TNF-α and IL-6, and reduce oxidative stress in the brain, circulatory system, and skin.

4. Wound Healing, Collagen Support, and Tissue Repair
Asiaticoside stimulates collagen production and fibroblast activity, speeding up wound healing and improving tissue integrity. Clinical evidence shows it can tighten the skin, reduce scarring, and improve microcirculation, making it a widely used ingredient in dermatology and cosmetic care.

5. Microcirculation and Vascular Protection
Centella strengthens capillary walls and enhances endothelial cell function, reducing symptoms like heavy legs, venous stagnation, and swelling. It can be especially beneficial in cases of venous insufficiency or impaired skin circulation.

6. Telomerase Activation and Cellular Longevity
One of Centella’s most fascinating benefits is its ability to stimulate telomerase enzyme activity, which protects the telomeres—the “caps” at the ends of chromosomes that safeguard DNA during cell division.
A 2019 study found that Gotu Kola increased telomerase expression by 8.8 times in cultured cells, suggesting powerful potential for slowing biological aging and supporting long-term cellular health.

Telomeres naturally shorten with each cell division, and environmental stress, inflammation, and free radicals can accelerate this. Once telomeres reach a critical length, cells enter a senescent state where they stop dividing and begin releasing pro-inflammatory signals that accelerate tissue aging and damage.

By naturally stimulating the body’s own telomerase production, Centella may protect DNA from damage and reduce mutation risk, helping to maintain optimal cellular function and longevity.

7. Relief from Anxiety and Panic
Several studies have demonstrated that Gotu Kola may significantly reduce symptoms of anxiety and panic attacks, particularly in individuals suffering from generalized anxiety disorder (GAD). This further reinforces its role as a natural calming and neuro-supportive agent.

Why We Included It in Lost Garden Formulas

We selected Centella asiatica for our premium Lost Garden formulations because it offers comprehensive support for mental clarity, emotional balance, and cellular regeneration – exactly where modern life places the greatest demands on the body.

This botanical powerhouse not only nourishes the nervous system but also supports the skin, vascular health, and cellular longevity. It works in synergy with other carefully selected ingredients like ashwagandha, ginseng, turmeric, and ginger, delivering targeted, natural support for balance and resilience from within.

Scientific References:

https://pmc.ncbi.nlm.nih.gov/articles/PMC8369046/pdf/jep-13-781.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC9650315/pdf/jer-18-5-330.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC7498642/pdf/fphar-11-568032.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC8627341/pdf/ECAM2021-5462633.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC3359802/pdf/ECAM2012-946259.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC3834700/pdf/PDIA-30-20289.pdf

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Our products containing the ingredient:

Beauty

Plant-based support for skin and hair – with pine bark extract, glycine, catalase and centella asiatica for your natural beauty ritual.

Eve

Premium herbal support for women 40+ – with ashwagandha, ginseng, and other natural extracts to complement a mindful daily routine.

Other ingredients:

Ashwagandha

A traditional herb that may help reduce the signs of aging, support muscles, joints, mental vitality, hormonal balance, and has stress-relieving and anti-anxiety effects.

Bromelain

An enzyme extracted from pineapple, known for its anti-inflammatory, pain-relieving, and digestion-supporting properties, as well as its potential to help maintain joint health.

Catalase enzyme

The catalase enzyme is one of nature's wonders, found in nearly all living organisms. Its primary function is to break down hydrogen peroxide molecules, which are byproducts of various oxidative processes in the human body.

Citrulline

An amino acid used by the body to produce nitric oxide, which is important for the circulatory system and muscle function. It is primarily used in sports supplements.

Collagen – Type II

In our body, collagen is the most abundant protein, particularly Type 1. It is found in muscles, bones, skin, blood vessels, the digestive system, and tendons.

Curcumin

Turmeric, derived from the root of the turmeric plant, is considered one of the most potent anti-inflammatory substances. Thanks to its strong antioxidant properties, it can neutralize free radicals, protecting the body from harmful chemical substances that can damage cells.

Devil’s Claw

Devil's Claw, also known as Harpagophytum procumbens, has a long-standing history of use in traditional medicine for treating inflammation.

Fenugreek

Known for improving blood sugar levels, enhancing libido, playing a role in improving hormonal balance, contributing to the maintenance of muscle mass, and supporting mental vitality.

Ginger

Widely known for its anti-inflammatory properties, which can help alleviate joint pain and support digestion.

Ginseng

Known for its energizing properties, ginseng improves physical and mental endurance and is classified as an adaptogenic herb.

Glycine

An essential amino acid that supports cognitive functions, promotes a healthy sleep cycle, and delays the signs of aging by playing a vital role in the formation and maintenance of collagen and elastin.

Gotu Kola

This plant is primarily used to improve cognitive functions, support skin health, promote wound healing, and reduce stress.

Maca

Maca is an adaptogenic herb whose primary purpose is to enhance the body's resilience to everyday stress responses.

Maritime Pine

Pycnogenol, the plant extract found in maritime pine, is rich in antioxidants and flavonoids, offering numerous health and beauty benefits for women.

Papain

Papain is a highly valuable proteolytic enzyme found in the fruit of the papaya plant (Carica papaya).

Piperine

Piperine, a naturally occurring bioactive compound found in black pepper and long pepper, is associated with numerous beneficial health effects.

Saw palmetto

This herb is primarily used to support prostate health, maintain hormonal balance, and preserve hair growth.

Ashwagandha

A traditional herb that may help reduce the signs of aging, support muscles, joints, mental vitality, hormonal balance, and has stress-relieving and anti-anxiety effects.

Bromelain

An enzyme extracted from pineapple, known for its anti-inflammatory, pain-relieving, and digestion-supporting properties, as well as its potential to help maintain joint health.

Catalase enzyme

The catalase enzyme is one of nature's wonders, found in nearly all living organisms. Its primary function is to break down hydrogen peroxide molecules, which are byproducts of various oxidative processes in the human body.

Citrulline

An amino acid used by the body to produce nitric oxide, which is important for the circulatory system and muscle function. It is primarily used in sports supplements.

Collagen – Type II

In our body, collagen is the most abundant protein, particularly Type 1. It is found in muscles, bones, skin, blood vessels, the digestive system, and tendons.

Curcumin

Turmeric, derived from the root of the turmeric plant, is considered one of the most potent anti-inflammatory substances. Thanks to its strong antioxidant properties, it can neutralize free radicals, protecting the body from harmful chemical substances that can damage cells.

Devil’s Claw

Devil's Claw, also known as Harpagophytum procumbens, has a long-standing history of use in traditional medicine for treating inflammation.

Fenugreek

Known for improving blood sugar levels, enhancing libido, playing a role in improving hormonal balance, contributing to the maintenance of muscle mass, and supporting mental vitality.

Ginger

Widely known for its anti-inflammatory properties, which can help alleviate joint pain and support digestion.

Ginseng

Known for its energizing properties, ginseng improves physical and mental endurance and is classified as an adaptogenic herb.

Glycine

An essential amino acid that supports cognitive functions, promotes a healthy sleep cycle, and delays the signs of aging by playing a vital role in the formation and maintenance of collagen and elastin.

Gotu Kola

This plant is primarily used to improve cognitive functions, support skin health, promote wound healing, and reduce stress.

Maca

Maca is an adaptogenic herb whose primary purpose is to enhance the body's resilience to everyday stress responses.

Maritime Pine

Pycnogenol, the plant extract found in maritime pine, is rich in antioxidants and flavonoids, offering numerous health and beauty benefits for women.

Papain

Papain is a highly valuable proteolytic enzyme found in the fruit of the papaya plant (Carica papaya).

Piperine

Piperine, a naturally occurring bioactive compound found in black pepper and long pepper, is associated with numerous beneficial health effects.

Saw palmetto

This herb is primarily used to support prostate health, maintain hormonal balance, and preserve hair growth.