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Glycine

The Smallest Amino Acid with Profound Impact

Glycine is the simplest amino acid in structure, yet it plays a crucial role in numerous physiological processes throughout the body. Beyond being a basic protein building block, glycine acts as a calming neurotransmitter, a key supporter of collagen synthesis, and a potent antioxidant and immune modulator. According to recent scientific research, glycine is found in virtually all tissues and is essential for maintaining long-term health—especially when the goal is regeneration, stress resilience, high-quality sleep, and cellular protection.

Scientifically Proven Benefits

1. Antioxidant Defense and Glutathione Production
Glycine is essential for the synthesis of glutathione, one of the body’s most powerful antioxidants. Glutathione neutralizes free radicals, detoxifies the liver, and protects cells from oxidative stress. Clinical studies show that glycine deficiency is strongly linked to chronic inflammation, metabolic syndrome, and premature cellular aging.

2. Anti-Inflammatory and Immune-Modulating Effects
Glycine helps reduce inflammatory cytokines such as IL-6 and TNF-α, supporting a balanced immune response. A 2023 study also highlighted its neuroprotective effects via regulation of microglial activity in the brain.

3. Collagen Synthesis and Skin Health
Glycine is a major building block of collagen, which is vital for skin elasticity, joint health, and connective tissue strength. Supplementation has been shown to improve wound healing, reduce joint pain, and enhance skin hydration and firmness.

4. Nervous System, Stress, and Sleep
As an inhibitory neurotransmitter, glycine calms the nervous system, promotes restful sleep, and reduces nighttime awakenings. Human studies demonstrate that as little as 3 grams per day significantly improves sleep quality, mental clarity, and daytime focus.

5. Metabolism, Blood Sugar, and Insulin Sensitivity
Glycine helps stabilize blood glucose levels, improves insulin sensitivity, and reduces inflammatory responses linked to hyperglycemia. A 2023 study reported that glycine supplementation lowered HbA1c and inflammation markers in people with type 2 diabetes.

6. Mitochondrial Function and Longevity
Glycine stimulates mitochondrial biogenesis, supports energy production, and promotes healthy cell division. Genetic studies show a link between glycine metabolism and increased lifespan, as well as reduced DNA damage.

Key Benefits at a Glance

  • Powerful antioxidant and cellular defense
  • Supports healthy skin, joints, and connective tissue
  • Enhances sleep quality and mental sharpness
  • Reduces inflammation and modulates immune function
  • Improves insulin sensitivity and metabolic balance
  • Protects the liver and supports detoxification
  • Essential for glutathione synthesis and mitochondrial health

Why It’s Included in Lost Garden Formulas

Glycine is far more than a “basic amino acid.” It’s a comprehensive cellular guardian, nervous system modulator, and skin-renewing compound. In Lost Garden formulations, glycine works synergistically with ingredients like pine bark extract, gotu kola, devil’s claw, and curcumin to support energy, tissue regeneration, hormonal harmony, and sleep quality. It is a cornerstone compound for any supplement designed to counteract the cellular stress of modern life—naturally, and with scientific backing.

Scientific References:

https://pmc.ncbi.nlm.nih.gov/articles/PMC10379184/pdf/ijms-24-11236.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC6627940/pdf/nutrients-11-01356.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC6424468/pdf/pgen.1007633.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC9615314/pdf/main.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC10828290/pdf/11357_2023_Article_970.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC6381570/pdf/OMCL2019-4248529.pdf

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Our products containing the ingredient:

Beauty

Plant-based support for skin and hair – with pine bark extract, glycine, catalase and centella asiatica for your natural beauty ritual.

Body

Premium herbal support for active living – with turmeric, bromelain, ginger, devil’s claw and more for mobility and overall balance.

Other ingredients:

Ashwagandha

A traditional herb that may help reduce the signs of aging, support muscles, joints, mental vitality, hormonal balance, and has stress-relieving and anti-anxiety effects.

Bromelain

An enzyme extracted from pineapple, known for its anti-inflammatory, pain-relieving, and digestion-supporting properties, as well as its potential to help maintain joint health.

Catalase enzyme

The catalase enzyme is one of nature's wonders, found in nearly all living organisms. Its primary function is to break down hydrogen peroxide molecules, which are byproducts of various oxidative processes in the human body.

Citrulline

An amino acid used by the body to produce nitric oxide, which is important for the circulatory system and muscle function. It is primarily used in sports supplements.

Collagen – Type II

In our body, collagen is the most abundant protein, particularly Type 1. It is found in muscles, bones, skin, blood vessels, the digestive system, and tendons.

Curcumin

Turmeric, derived from the root of the turmeric plant, is considered one of the most potent anti-inflammatory substances. Thanks to its strong antioxidant properties, it can neutralize free radicals, protecting the body from harmful chemical substances that can damage cells.

Devil’s Claw

Devil's Claw, also known as Harpagophytum procumbens, has a long-standing history of use in traditional medicine for treating inflammation.

Fenugreek

Known for improving blood sugar levels, enhancing libido, playing a role in improving hormonal balance, contributing to the maintenance of muscle mass, and supporting mental vitality.

Ginger

Widely known for its anti-inflammatory properties, which can help alleviate joint pain and support digestion.

Ginseng

Known for its energizing properties, ginseng improves physical and mental endurance and is classified as an adaptogenic herb.

Glycine

An essential amino acid that supports cognitive functions, promotes a healthy sleep cycle, and delays the signs of aging by playing a vital role in the formation and maintenance of collagen and elastin.

Gotu Kola

This plant is primarily used to improve cognitive functions, support skin health, promote wound healing, and reduce stress.

Maca

Maca is an adaptogenic herb whose primary purpose is to enhance the body's resilience to everyday stress responses.

Maritime Pine

Pycnogenol, the plant extract found in maritime pine, is rich in antioxidants and flavonoids, offering numerous health and beauty benefits for women.

Papain

Papain is a highly valuable proteolytic enzyme found in the fruit of the papaya plant (Carica papaya).

Piperine

Piperine, a naturally occurring bioactive compound found in black pepper and long pepper, is associated with numerous beneficial health effects.

Saw palmetto

This herb is primarily used to support prostate health, maintain hormonal balance, and preserve hair growth.

Ashwagandha

A traditional herb that may help reduce the signs of aging, support muscles, joints, mental vitality, hormonal balance, and has stress-relieving and anti-anxiety effects.

Bromelain

An enzyme extracted from pineapple, known for its anti-inflammatory, pain-relieving, and digestion-supporting properties, as well as its potential to help maintain joint health.

Catalase enzyme

The catalase enzyme is one of nature's wonders, found in nearly all living organisms. Its primary function is to break down hydrogen peroxide molecules, which are byproducts of various oxidative processes in the human body.

Citrulline

An amino acid used by the body to produce nitric oxide, which is important for the circulatory system and muscle function. It is primarily used in sports supplements.

Collagen – Type II

In our body, collagen is the most abundant protein, particularly Type 1. It is found in muscles, bones, skin, blood vessels, the digestive system, and tendons.

Curcumin

Turmeric, derived from the root of the turmeric plant, is considered one of the most potent anti-inflammatory substances. Thanks to its strong antioxidant properties, it can neutralize free radicals, protecting the body from harmful chemical substances that can damage cells.

Devil’s Claw

Devil's Claw, also known as Harpagophytum procumbens, has a long-standing history of use in traditional medicine for treating inflammation.

Fenugreek

Known for improving blood sugar levels, enhancing libido, playing a role in improving hormonal balance, contributing to the maintenance of muscle mass, and supporting mental vitality.

Ginger

Widely known for its anti-inflammatory properties, which can help alleviate joint pain and support digestion.

Ginseng

Known for its energizing properties, ginseng improves physical and mental endurance and is classified as an adaptogenic herb.

Glycine

An essential amino acid that supports cognitive functions, promotes a healthy sleep cycle, and delays the signs of aging by playing a vital role in the formation and maintenance of collagen and elastin.

Gotu Kola

This plant is primarily used to improve cognitive functions, support skin health, promote wound healing, and reduce stress.

Maca

Maca is an adaptogenic herb whose primary purpose is to enhance the body's resilience to everyday stress responses.

Maritime Pine

Pycnogenol, the plant extract found in maritime pine, is rich in antioxidants and flavonoids, offering numerous health and beauty benefits for women.

Papain

Papain is a highly valuable proteolytic enzyme found in the fruit of the papaya plant (Carica papaya).

Piperine

Piperine, a naturally occurring bioactive compound found in black pepper and long pepper, is associated with numerous beneficial health effects.

Saw palmetto

This herb is primarily used to support prostate health, maintain hormonal balance, and preserve hair growth.