Skip to content

Lost Garden

back

Devil’s Claw

A Targeted Natural Solution for Musculoskeletal Discomfort
Devil’s claw, also known as the “desert claw,” is a medicinal plant native to the semi-arid regions of southern Africa. Its name comes from the hooked shape of its fruit, but its real value lies in the active compound harpagoside, which is now being studied as a natural alternative to non-steroidal anti-inflammatory drugs (NSAIDs).

For centuries, extracts from the root have been used in traditional medicine to treat back pain, joint stiffness, rheumatic symptoms, and digestive complaints. In the last two decades, however, devil’s claw has gained significant attention in clinical research – and for good reason.

How Does It Work at the Cellular Level?

  • Harpagoside and related iridoid glycosides act on several key points in the body’s inflammatory processes:
  • Inhibition of NF-κB: one of the body’s primary pro-inflammatory signaling pathways. Devil’s claw extract has been shown to reduce NF-κB activation in synovial cells within 24 hour
  • Suppression of COX-2 enzyme: reduces the production of prostaglandins, which are responsible for pain and swelling.
  • Reduction of nitric oxide (NO) and iNOS: helps lower oxidative stress and minimizes tissue damage in inflamed areas.
  • Downregulation of inflammatory cytokines: consistent use can reduce TNF-α, IL-1β, and IL-6 levels by 20–40%, helping to prevent chronic inflammation
  • Protection of chondrocytes: helps prevent the breakdown of cartilage and supports regeneration of joint tissues

Clinical Findings – What Do Studies Say?

  • In randomized clinical trials, daily supplementation with 2400 mg of devil’s claw extract significantly reduced pain and improved mobility in patients with osteoarthritis – with effects seen after just two weeks, and peaking around 8 weeks.
  • In placebo-controlled studies, the pain-relieving effect of the extract was comparable to NSAIDs like diclofenac, but with fewer gastrointestinal side effects.
  • In patients with chronic knee or hip pain, pain intensity was reduced by 40–50%, especially regarding morning stiffness and limited range of motion.

Synergy with Other Botanicals – Not Just a Solo Ingredient
A 2021 study found that the combination of devil’s claw, curcumin, and bromelain was significantly more effective than any single component alone.
This trio performed particularly well in cases of joint inflammation, muscle stiffness, and restricted mobility. Inflammatory biomarkers such as CRP and IL-6 decreased more significantly under the combined protocol than with monotherapy.

Why Is It Included in Lost Garden Products?
The devil’s claw extract used in Lost Garden formulations is standardized for harpagoside content, ensuring consistent, measurable efficacy.
We do not use raw ground root, but rather a high-potency extract – meaning each capsule contains a significantly stronger dose than traditional preparations.

At Lost Garden, devil’s claw is not just a joint-support ingredient: it offers comprehensive musculoskeletal support, antioxidant protection, and is well tolerated for long-term use.

Personal Note
Devil’s claw plays a key role not only in Lost Garden product development – it holds deep personal significance for me as well. During my university studies, I chose this plant as the central topic of my thesis, where I explored its mechanisms of action and therapeutic potential in detail.
A full chapter was dedicated to the Lost Garden Body formula, which combines devil’s claw with curcumin and bromelain in a synergistic, evidence-based approach.
This research and development process reflects my core belief that nature and science can truly work hand in hand in premium-quality nutrition.

Scientific References:

https://pmc.ncbi.nlm.nih.gov/articles/PMC8398729/pdf/pharmaceuticals-14-00726.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC9182060/pdf/molecules-27-03637.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC7551290/pdf/nutrients-12-02545.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC520753/pdf/1472-6882-4-13.pdf

https://pmc.ncbi.nlm.nih.gov/articles/PMC9026917/pdf/pharmaceuticals-15-00457.pdf

back

Our products containing the ingredient:

Body

Premium herbal support for active living – with turmeric, bromelain, ginger, devil’s claw and more for mobility and overall balance.

Other ingredients:

Ashwagandha

A traditional herb that may help reduce the signs of aging, support muscles, joints, mental vitality, hormonal balance, and has stress-relieving and anti-anxiety effects.

Bromelain

An enzyme extracted from pineapple, known for its anti-inflammatory, pain-relieving, and digestion-supporting properties, as well as its potential to help maintain joint health.

Catalase enzyme

The catalase enzyme is one of nature's wonders, found in nearly all living organisms. Its primary function is to break down hydrogen peroxide molecules, which are byproducts of various oxidative processes in the human body.

Citrulline

An amino acid used by the body to produce nitric oxide, which is important for the circulatory system and muscle function. It is primarily used in sports supplements.

Collagen – Type II

In our body, collagen is the most abundant protein, particularly Type 1. It is found in muscles, bones, skin, blood vessels, the digestive system, and tendons.

Curcumin

Turmeric, derived from the root of the turmeric plant, is considered one of the most potent anti-inflammatory substances. Thanks to its strong antioxidant properties, it can neutralize free radicals, protecting the body from harmful chemical substances that can damage cells.

Devil’s Claw

Devil's Claw, also known as Harpagophytum procumbens, has a long-standing history of use in traditional medicine for treating inflammation.

Fenugreek

Known for improving blood sugar levels, enhancing libido, playing a role in improving hormonal balance, contributing to the maintenance of muscle mass, and supporting mental vitality.

Ginger

Widely known for its anti-inflammatory properties, which can help alleviate joint pain and support digestion.

Ginseng

Known for its energizing properties, ginseng improves physical and mental endurance and is classified as an adaptogenic herb.

Glycine

An essential amino acid that supports cognitive functions, promotes a healthy sleep cycle, and delays the signs of aging by playing a vital role in the formation and maintenance of collagen and elastin.

Gotu Kola

This plant is primarily used to improve cognitive functions, support skin health, promote wound healing, and reduce stress.

Maca

Maca is an adaptogenic herb whose primary purpose is to enhance the body's resilience to everyday stress responses.

Maritime Pine

Pycnogenol, the plant extract found in maritime pine, is rich in antioxidants and flavonoids, offering numerous health and beauty benefits for women.

Papain

Papain is a highly valuable proteolytic enzyme found in the fruit of the papaya plant (Carica papaya).

Piperine

Piperine, a naturally occurring bioactive compound found in black pepper and long pepper, is associated with numerous beneficial health effects.

Saw palmetto

This herb is primarily used to support prostate health, maintain hormonal balance, and preserve hair growth.

Ashwagandha

A traditional herb that may help reduce the signs of aging, support muscles, joints, mental vitality, hormonal balance, and has stress-relieving and anti-anxiety effects.

Bromelain

An enzyme extracted from pineapple, known for its anti-inflammatory, pain-relieving, and digestion-supporting properties, as well as its potential to help maintain joint health.

Catalase enzyme

The catalase enzyme is one of nature's wonders, found in nearly all living organisms. Its primary function is to break down hydrogen peroxide molecules, which are byproducts of various oxidative processes in the human body.

Citrulline

An amino acid used by the body to produce nitric oxide, which is important for the circulatory system and muscle function. It is primarily used in sports supplements.

Collagen – Type II

In our body, collagen is the most abundant protein, particularly Type 1. It is found in muscles, bones, skin, blood vessels, the digestive system, and tendons.

Curcumin

Turmeric, derived from the root of the turmeric plant, is considered one of the most potent anti-inflammatory substances. Thanks to its strong antioxidant properties, it can neutralize free radicals, protecting the body from harmful chemical substances that can damage cells.

Devil’s Claw

Devil's Claw, also known as Harpagophytum procumbens, has a long-standing history of use in traditional medicine for treating inflammation.

Fenugreek

Known for improving blood sugar levels, enhancing libido, playing a role in improving hormonal balance, contributing to the maintenance of muscle mass, and supporting mental vitality.

Ginger

Widely known for its anti-inflammatory properties, which can help alleviate joint pain and support digestion.

Ginseng

Known for its energizing properties, ginseng improves physical and mental endurance and is classified as an adaptogenic herb.

Glycine

An essential amino acid that supports cognitive functions, promotes a healthy sleep cycle, and delays the signs of aging by playing a vital role in the formation and maintenance of collagen and elastin.

Gotu Kola

This plant is primarily used to improve cognitive functions, support skin health, promote wound healing, and reduce stress.

Maca

Maca is an adaptogenic herb whose primary purpose is to enhance the body's resilience to everyday stress responses.

Maritime Pine

Pycnogenol, the plant extract found in maritime pine, is rich in antioxidants and flavonoids, offering numerous health and beauty benefits for women.

Papain

Papain is a highly valuable proteolytic enzyme found in the fruit of the papaya plant (Carica papaya).

Piperine

Piperine, a naturally occurring bioactive compound found in black pepper and long pepper, is associated with numerous beneficial health effects.

Saw palmetto

This herb is primarily used to support prostate health, maintain hormonal balance, and preserve hair growth.